1001 Baltimore Pike

Springfield, PA

257 West Cayuga Street

Philadelphia, PA

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(267) 368-6953

Welcome to West Cayuga Medicine REMS-Certified SPRAVATO® Treatment Center

Don’t let depression keep you in the dark

Indications for SPRAVATO® Use

SPRAVATO® (esketamine) Nasal Spray is indicated for the treatment of two critical conditions:

Treatment-resistant depression (TRD) in adults.

Depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior.

How SPRAVATO® Works

SPRAVATO® is different because it acts on the glutamate pathway

The primary antidepressant activity of SPRAVATO® is not believed to directly involve inhibition of serotonin or norepinephrine reuptake.

The precise mechanism of action (MOA) is unknown.3-6

SPRAVATO® is an NMDA receptor antagonist. An NMDA receptor is an ionotropic glutamate receptor.3

SPRAVATO® hypothesized MOA.

NMDA=N-methyl-D-aspartate.

  • Clinical study results suggest that glutamate transmission is abnormally regulated in multiple areas of the brain of individuals with depression 7,8
  • Antagonism of the NMDA receptor and AMPA receptor activation leads to downstream release of BDNF and activation of kinases 9-11
  • BDNF expression and downstream signaling are thought to enhance neurogenesis and mediation of synaptic excitability and plasticity 12,13
  • It is important to note that the relationship between this pathway and the clinical effects of depression have not been established
SPRAVATO® is different because it acts on the glutamate pathway

The primary antidepressant activity of SPRAVATO® is not believed to directly involve inhibition of serotonin or norepinephrine reuptake.

The precise mechanism of action (MOA) is unknown.
SPRAVATO® is an NMDA receptor antagonist. An NMDA receptor is an ionotropic glutamate receptor.

Interested in knowing more about SPRAVATO®?

Thank you for exploring West Cayuga Medicine REMS-Certified SPRAVATO® Treatment Center. For further information or assistance, please don’t hesitate to contact us. Together, let’s continue striving for you improvement in mental health.

Office Hours:

West Cayuga Medicine at Springfield
Mon-Fri
Saturday

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